URI1 Antibody (PACO05616)
- SKU:
- PACO05616
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
URI1 Antibody (PACO05616)
The URI1 Antibody (PACO05616) is a highly specific and reliable tool for researchers studying the URI1 protein and its role in cellular processes. This polyclonal antibody, produced in rabbits, has been validated for use in various experimental applications including Western blot and immunofluorescence. URI1 is a key player in regulating gene expression and cell growth, making it a promising target for cancer research and drug development. By detecting and analyzing URI1 protein levels in different cell types, researchers can gain valuable insights into its functions and potential therapeutic implications.
Whether investigating the molecular mechanisms of URI1 in cancer progression or exploring its involvement in other biological pathways, the URI1 Antibody (PACO05616) offers a valuable tool for advancing scientific understanding in the field of molecular biology and oncology.
| Antibody Name: | URI1 Antibody (PACO05616) |
| Antibody SKU: | PACO05616 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:40000, WB:1:500-1:2000, IHC:1:100-1:300 |
| Species Reactivity: | Human |
| Immunogen: | Synthesized peptide derived from the C-terminal region of human RMP. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | URI1; C19orf2; NNX3; PPP1R19; RMP; URI; Unconventional prefoldin RPB5 interactor 1; Protein NNX3; Protein phosphatase 1 regulatory subunit 19; RNA polymerase II subunit 5-mediating protein; RPB5-mediating protein |
| UniProt Protein Function: | RMP: Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein. Homodimer. Component of the URI complex that contains PFDN2, POLR2E/RPB5, RUVBL2, RUVBL1 and URI1. Interacts with PPP1CC; the interaction is phosphorylation-dependent and occurs in a growth factor-dependent manner. Interacts with PFDN2, PFDN4 and STAP1; the interactions are phosphorylation-dependent and occurs in a growth-dependent manner in the mitochondrion. Interacts (via the middle C-terminus region) with GTF2F1 and GTF2F2. Interacts with DMAP1, POLR2E/RPB5 and UXT. Ubiquitous. Expressed in ovarian cancers. Expressed strongly in skeletal muscle. Expressed weakly in brain, heart, pancreas and in prostate epithelial cells. Belongs to the RNA polymerase II subunit 5-mediating protein family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 19q12 Cellular Component: mitochondrion; dendrite; cytoplasm; DNA-directed RNA polymerase II, core complex; nucleus Molecular Function:phosphatase inhibitor activity; protein binding; chromatin binding; protein phosphatase inhibitor activity Biological Process: regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; response to virus; regulation of cell growth; negative regulation of transcription from RNA polymerase II promoter |
| NCBI Summary: | This gene encodes member of the prefoldin family of molecular chaperones. The encoded protein functions as a scaffolding protein and plays roles in ubiquitination and transcription, in part though interactions with the RNA polymerase II subunit RPB5. This gene may play a role in multiple malignancies including ovarian cancer and hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 22. [provided by RefSeq, Nov 2011] |
| UniProt Code: | O94763 |
| NCBI GenInfo Identifier: | 239938855 |
| NCBI Gene ID: | 8725 |
| NCBI Accession: | O94763.3 |
| UniProt Secondary Accession: | O94763,Q8TC23, Q9UNU3, A8K805, H7BY42, |
| UniProt Related Accession: | O94763 |
| Molecular Weight: | 535 |
| NCBI Full Name: | Unconventional prefoldin RPB5 interactor 1 |
| NCBI Synonym Full Names: | URI1, prefoldin-like chaperone |
| NCBI Official Symbol: | URI1Â Â |
| NCBI Official Synonym Symbols: | RMP; URI; NNX3; C19orf2; PPP1R19Â Â |
| NCBI Protein Information: | unconventional prefoldin RPB5 interactor 1; RPB5-mediating protein; protein phosphatase 1 regulatory subunit 19; protein phosphatase 1, regulatory subunit 19; RNA polymerase II subunit 5-mediating protein |
| UniProt Protein Name: | Unconventional prefoldin RPB5 interactor 1 |
| UniProt Synonym Protein Names: | Protein NNX3; Protein phosphatase 1 regulatory subunit 19; RNA polymerase II subunit 5-mediating protein; RPB5-mediating protein |
| Protein Family: | Unconventional prefoldin RPB5 interactor |
| UniProt Gene Name: | URI1Â Â |
| UniProt Entry Name: | RMP_HUMAN |
Related Products
URI1 Antibody (PACO55866)
URI1 Antibody (PACO23476)
