The UPRT Polyclonal Antibody (PACO38698) is a valuable tool for researchers studying the UPRT protein, an essential enzyme involved in pyrimidine biosynthesis. This antibody is raised in rabbits and is highly specific for human samples, making it ideal for Western blot applications. By targeting the UPRT protein, this antibody allows for the detection and analysis of UPRT expression in a variety of cell types, supporting research in fields such as genetics and drug development.
UPRT, or uracil phosphoribosyltransferase, plays a crucial role in nucleotide metabolism by catalyzing the conversion of uracil to uridine monophosphate. Dysregulation of UPRT has been linked to various disorders including cancer and neurological diseases, making it a promising target for therapeutic interventions. By investigating the function and regulation of UPRT, researchers can uncover new insights into disease pathways and potential treatment strategies.
Antibody Name:
UPRT Antibody (PACO38698)
Antibody SKU:
PACO38698
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Uracil phosphoribosyltransferase homolog protein (1-309AA)
UPRT: an enzyme which catalyzes the conversion of uracil and 5-phosphoribosyl-1-R-diphosphate to uridine monophosphate (UMP). This reaction is an important part of nucleotide metabolism, specifically the pyrimidine salvage pathway. The enzyme localizes to the nucleus and cytoplasm. The protein is a potential target for rational design of drugs to treat parasitic infections and cancer. [provided by RefSeq, Nov 2009]Protein type: EC 2.4.2.9; Transferase; Nucleotide Metabolism - pyrimidineChromosomal Location of Human Ortholog: Xq13.3Cellular Component: cytosolMolecular Function: protein binding; uridine kinase activityBiological Process: pyrimidine base metabolic process; pyrimidine nucleoside salvage
UniProt Protein Details:
NCBI Summary:
This gene encodes uracil phosphoribosyltransferase, which catalyzes the conversion of uracil and 5-phosphoribosyl-1-R-diphosphate to uridine monophosphate (UMP). This reaction is an important part of nucleotide metabolism, specifically the pyrimidine salvage pathway. The enzyme localizes to the nucleus and cytoplasm. The protein is a potential target for rational design of drugs to treat parasitic infections and cancer. [provided by RefSeq, Nov 2009]
