UPP2 Antibody (PACO31004)
- SKU:
- PACO31004
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
UPP2 Antibody (PACO31004)
The UPP2 Polyclonal Antibody (PACO31004) is a vital tool for researchers studying the UPP2 protein, which is involved in the ubiquitin proteasome pathway and is essential for protein degradation and cellular regulation. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically recognizing the UPP2 protein, researchers can accurately detect and analyze its expression in a variety of cell types, making it an indispensable tool for studies in molecular biology and cell physiology.UPP2 is a key player in maintaining cellular homeostasis by ensuring the timely degradation of proteins, controlling processes such as cell cycle progression, signal transduction, and response to stress.
Dysregulation of the ubiquitin proteasome pathway, including alterations in UPP2 function, has been linked to a variety of diseases, including neurodegenerative disorders, cancer, and autoimmune conditions. Investigating the role of UPP2 with the help of this antibody is essential for uncovering new therapeutic strategies that target protein degradation pathways for the treatment of these diseases.
| Antibody Name: | UPP2 Antibody (PACO31004) |
| Antibody SKU: | PACO31004 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human Uridine phosphorylase 2 protein (1-317AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot All lanes: UPP2 antibody at 4µg/ml Lane 1: Mouse kidney tissue Lane 2: Mouse brain tissue Lane 3: Hela whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 36, 42 kDa Observed band size: 36 kDa . |
| Background: | Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Shows substrate specificity and accept uridine, deoxyuridine, and thymidine as well as the two pyrimidine nucleoside analogs 5-fluorouridine and 5-fluoro-2(')-deoxyuridine as substrates. |
| Synonyms: | Uridine phosphorylase 2 (UPase 2) (UrdPase 2) (EC 2.4.2.3), UPP2 |
| UniProt Protein Function: | UPP2: Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Shows substrate specificity and accept uridine, deoxyuridine, and thymidine as well as the two pyrimidine nucleoside analogs 5-fluorouridine and 5-fluoro-2(')-deoxyuridine as substrates. Belongs to the PNP/UDP phosphorylase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Nucleotide Metabolism - pyrimidine; Xenobiotic Metabolism - drug metabolism - other enzymes; Phosphorylase; Transferase; EC 2.4.2.3 Chromosomal Location of Human Ortholog: 2q24.1 Cellular Component: cytosol; type III intermediate filament Molecular Function:protein binding; uridine phosphorylase activity Biological Process: pyrimidine nucleoside catabolic process; pyrimidine nucleoside salvage |
| UniProt Code: | O95045 |
| NCBI GenInfo Identifier: | 37538021 |
| NCBI Gene ID: | 151531 |
| NCBI Accession: | O95045.1 |
| UniProt Secondary Accession: | O95045,B3KV87, |
| UniProt Related Accession: | O95045 |
| Molecular Weight: | 41,602 Da |
| NCBI Full Name: | Uridine phosphorylase 2 |
| NCBI Synonym Full Names: | uridine phosphorylase 2 |
| NCBI Official Symbol: | UPP2Â Â |
| NCBI Official Synonym Symbols: | UP2; UPASE2; UDRPASE2Â Â |
| NCBI Protein Information: | uridine phosphorylase 2 |
| UniProt Protein Name: | Uridine phosphorylase 2 |
| Protein Family: | Uridine phosphorylase |
| UniProt Gene Name: | UPP2Â Â |
| UniProt Entry Name: | UPP2_HUMAN |
| ELISA Kits |
| Human UPP2 ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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