The UPP2 Polyclonal Antibody (PAC020838) is a specialized tool for researchers studying the enzyme UPP2, which is involved in the ubiquitin-proteasome pathway. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blotting applications. By binding to the UPP2 protein, this antibody enables accurate detection and analysis of UPP2 levels in various cell types.The ubiquitin-proteasome pathway is a fundamental process in the regulation of protein turnover and degradation within cells. UPP2 plays a key role in this pathway by promoting the degradation of target proteins marked with ubiquitin tags.
Research into UPP2 function is essential for understanding how protein degradation is controlled and how it contributes to various cellular processes.By utilizing the UPP2 Polyclonal Antibody in their studies, researchers can gain valuable insights into the role of UPP2 in protein degradation and its implications for cellular function. This antibody is a valuable tool for investigations in areas such as cell biology, biochemistry, and drug development, providing a deeper understanding of the mechanisms underlying protein turnover in health and disease.
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO20838(UPP2 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200).
Gel: 6%SDS-PAGE,Lysate: 40 μgPrimary antibody: PACO20838(UPP2 Antibody) at dilution 1/400 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 40 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20838(UPP2 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Shows substrate specificity and accept uridine, deoxyuridine, and thymidine as well as the two pyrimidine nucleoside analogs 5-fluorouridine and 5-fluoro-2(')-deoxyuridine as substrates.
Synonyms:
uridine phosphorylase 2
UniProt Protein Function:
UPP2: Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Shows substrate specificity and accept uridine, deoxyuridine, and thymidine as well as the two pyrimidine nucleoside analogs 5-fluorouridine and 5-fluoro-2(')-deoxyuridine as substrates. Belongs to the PNP/UDP phosphorylase family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:
Protein type:Nucleotide Metabolism - pyrimidine; Xenobiotic Metabolism - drug metabolism - other enzymes; Phosphorylase; Transferase; EC 2.4.2.3
Chromosomal Location of Human Ortholog: 2q24.1
Cellular Component: cytosol; type III intermediate filament
