UPF3B Rabbit Polyclonal Antibody (CAB15184)
- SKU:
- CAB15184
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Product Name: | UPF3B Rabbit Polyclonal Antibody |
SKU: | CAB15184 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human UPF3B (NP_075386.1). |
Sequence: | MKEE KEHR PKEK RVTL LTPA GATG SGGG TSGD SSKG EDKQ DRNK EKKE ALSK VVIR RLPP TLTK EQLQ EHLQ PMPE HDYF EFFS NDTS LYPH MYAR AYIN FKNQ EDII LFRD RFDG YVFL DNKG QEYP AIVE FAPF QKAA KKKT KKRD TKVG TIDD DPEY RKFL ESYA TDNE KMTS TPET |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | MRX62; MRX82; UPF3X; HUPF3B; MRXS14; RENT3B; UPF3BP1; UPF3BP2; UPF3BP3; Upf3p-X; UPF3B |
Positive Sample: | Mouse testis,Mouse heart |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus. |
Calculated MW: | 58kDa |
Observed MW: | 56kDa |
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 65109 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |