UPF2 Rabbit Polyclonal Antibody (CAB7091)
- SKU:
- CAB7091
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | UPF2 Rabbit Polyclonal Antibody |
SKU: | CAB7091 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1153-1272 of human UPF2 (NP_542166.1). |
Sequence: | GPPL GGGE GEAE SADT MPFV MLTR KGNK QQFK ILNV PMSS QLAA NHWN QQQA EQEE RMRM KKLT LDIN ERQE QEDY QEML QSLA QRPA PANT NRER RPRY QHPK GAPN ADLI FKTG GRRR |
Tested Applications: | WB IHC-P IP ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells |
Synonyms: | HUPF2; RENT2; smg-3; UPF2 |
Positive Sample: | Jurkat,293T |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, perinuclear region. |
Calculated MW: | 148kDa |
Observed MW: | 170kDa |
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene; both variants encode the same protein.
Purification Method: | Affinity purification |
Gene ID: | 26019 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |