UPF1/RENT1 Rabbit Polyclonal Antibody (CAB1521)
- SKU:
- CAB1521
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
Product Name: | UPF1/RENT1 Rabbit Polyclonal Antibody |
SKU: | CAB1521 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 819-1118 of human UPF1/RENT1 (NP_002902.2). |
Sequence: | QEVE IASV DAFQ GREK DFII LSCV RANE HQGI GFLN DPRR LNVA LTRA RYGV IIVG NPKA LSKQ PLWN HLLN YYKE QKVL VEGP LNNL RESL MQFS KPRK LVNT INPG ARFM TTAM YDAR EAII PGSV YDRS SQGR PSSM YFQT HDQI GMIS AGPS HVAA MNIP IPFN LVMP PMPP PGYF GQAN GPAA GRGT PKGK TGRG GRQK NRFG LPGP SQTN LPNS QASQ DVAS QPFS QGAL TQGY ISMS QPSQ MSQP GLSQ PELS QDSY LGDE FKSQ IDVA LSQD STYQ GERA YQHG GVTG LSQY |
Tested Applications: | WB IF/ICC IP ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells |
Synonyms: | UTF; HUPF1; NORF1; RENT1; smg-2; pNORF1; UPF1/RENT1 |
Positive Sample: | HeLa,293T,SH-SY5Y,K-562,HL-60,Mouse liver |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus, P-body. |
Calculated MW: | 124kDa |
Observed MW: | 130kDa |
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 5976 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |