The UPB1 Polyclonal Antibody (CAB15452) is a powerful tool for researchers studying the UPB1 protein, a critical enzyme involved in the biosynthesis of pantothenic acid. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By binding to the UPB1 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential component for studies in biochemistry and metabolic research.UPB1 is a key player in the pantothenate and CoA biosynthesis pathway, with dysregulation of its function linked to various metabolic disorders.
Research into the function and regulation of UPB1 is crucial for understanding its role in human health and disease, particularly in conditions related to CoA metabolism and vitamin B5 deficiency. By utilizing the UPB1 Polyclonal Antibody, researchers can gain valuable insights into the biochemical pathways involving UPB1, paving the way for potential therapeutic interventions and treatments in the future.
Product Name:
UPB1 Rabbit Polyclonal Antibody
SKU:
CAB15452
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human UPB1 (NP_057411.1).
This gene encodes a protein that belongs to the CN hydrolase family. Beta-ureidopropionase catalyzes the last step in the pyrimidine degradation pathway. The pyrimidine bases uracil and thymine are degraded via the consecutive action of dihydropyrimidine dehydrogenase (DHPDH), dihydropyrimidinase (DHP) and beta-ureidopropionase (UP) to beta-alanine and beta-aminoisobutyric acid, respectively. UP deficiencies are associated with N-carbamyl-beta-amino aciduria and may lead to abnormalities in neurological activity.
Purification Method:
Affinity purification
Gene ID:
51733
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using UPB1 Rabbit pAb (CAB15452) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
