uPAR/U-PAR Monoclonal Antibody (CAB23293)
- SKU:
- CAB23293
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- IF
Description
| Product Name: | uPAR/U-PAR Monoclonal Antibody |
| SKU: | CAB23293 |
| Size: | 20uL, 100uL |
| Isotype: | IgG |
| Host Species: | Rabbit |
| Reactivity: | Human |
| Immunogen: | Recombinant protein of human uPAR/U-PAR. |
| Sequence: | LRCM QCKT NGDC RVEE CALG QDLC RTTI VRLW EEGE ELEL VEKS CTHS EKTN RTLS YRTG LKIT SLTE VVCG LDLC NQGN SGRA VTYS RSRY LECI SCGS SDMS CERG RHQS LQCR SPEE QCLD VVTH WIQE GEEG RPKD DRHL RGCG YLPG CPGS NGFH NNDT FHFL KCCN TTKC NEGP ILEL ENLP QNGR QCYS CKGN STHG CSSE ETFL IDCR GPMN QCLV ATGT HEPK NQSY MVRG CATA SMCQ HAHL GDAF SMNH IDVS CCTK SGCN HPDL DVQY RSG |
| Tested Applications: | IF/ICC ELISA |
| Recommended Dilution: | IF/ICC,1:100 - 1:500 |
| Synonyms: | CD87; UPAR; URKR; U-PAR; uPAR/U-PAR |
| Conjugate: | Unconjugated |
| Cellular Localization: | Cell membrane, Cell projection, GPI-anchor, Lipid-anchor, Secreted, invadopodium membrane. |
| Calculated MW: | 37kDa |
| Observed MW: | Refer to figures |
This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined.
| Purification Method: | Affinity purification |
| Gene ID: | 5329 |
| Clone Number: | ARC60627 |
| Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3. |
 | Immunofluorescence analysis of U-87MG cells using uPAR/U-PAR Rabbit mAb (CAB23293) at dilution of 1:300 (40x lens). Blue: DAPI for nuclear staining. |
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