The UNC80 Polyclonal Antibody (PAC050922) is a valuable tool for researchers studying the UNC80 protein, an essential component of the NALCN sodium leak channel complex. This antibody, produced in rabbits, shows high reactivity with human samples and has been validated for use in Western blot applications. It specifically targets the UNC80 protein, allowing for accurate detection and analysis in a variety of cell types.UNC80 is crucial for the proper functioning of the NALCN channel, which plays a key role in neuronal excitability and regulation of resting membrane potential. Dysregulation of this channel complex has been implicated in neurological disorders such as epilepsy and intellectual disability.
Research into the activity and function of UNC80 is essential for understanding the molecular mechanisms underlying these conditions and developing potential therapeutic strategies.With its specificity and sensitivity, the UNC80 Polyclonal Antibody is an invaluable tool for scientists investigating the role of UNC80 in neurological processes and diseases. Its use in experiments related to ion channel biology, neuroscience, and neurodevelopmental disorders can provide valuable insights into the function of the NALCN channel complex and its impact on neuronal activity.
Immunofluorescent analysis of HepG2 cells using PACO50922 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Western Blot. Positive WB detected in Recombinant protein. All lanes: UNC80 antibody at 3.5µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 59 kDa. Observed band size: 59 kDa.
Background:
Component of the NALCN sodium channel complex, required for channel regulation. This complex is a cation channel activated by neuropeptides substance P, neurotensin, and extracellular calcium that regulates neuronal excitability by controlling the sizes of NALCN-dependent sodium-leak current. UNC80 is essential for NALCN sensitivity to extracellular calcium.
Synonyms:
Protein unc-80 homolog, UNC80, C2orf21 KIAA1843
UniProt Protein Function:
Component of the NALCN sodium channel complex, required for channel regulation. This complex is a cation channel activated by neuropeptides substance P, neurotensin, and extracellular calcium that regulates neuronal excitability by controlling the sizes of NALCN-dependent sodium-leak current. UNC80 is essential for NALCN sensitivity to extracellular calcium.
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a component of a voltage-independent 'leak' ion-channel complex, in which it performs essential functions, such as serving as a bridge between two other components (sodium leak channel non-selective and UNC79) and as a scaffold for Src kinases. Leak channels play an importnat role in establishment and maintenance of resting membrane potentials in neurons. Mutations in this gene are associated with congenital infantile encephalopathy, intellectual disability and growth issues. [provided by RefSeq, Aug 2016]
