The UNC5C Polyclonal Antibody (CAB14809) is a valuable tool for researchers studying UNC5C, a protein involved in axon guidance and cell apoptosis. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the UNC5C protein, this antibody allows for the detection and analysis of UNC5C in various cell types, making it ideal for investigations in neuroscience and developmental biology.UNC5C is a netrin receptor that mediates the repulsive effects of netrin-1 on axon guidance, playing a crucial role in the development of the nervous system.
Additionally, UNC5C is involved in programmed cell death, contributing to the regulation of tissue homeostasis. Research on UNC5C is important for understanding neural development and identifying potential targets for neurodegenerative diseases, such as Alzheimer's and Parkinson's.By utilizing the UNC5C Polyclonal Antibody, researchers can gain valuable insights into the functions and mechanisms of UNC5C, paving the way for advancements in neurobiology and potential therapeutic interventions for neurological disorders.
Product Name:
UNC5C Rabbit Polyclonal Antibody
SKU:
CAB14809
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 300-360 of human UNC5C (NP_003719.3).
Cell junction, Cell membrane, Single-pass type I membrane protein, synapse, synaptosome.
Calculated MW:
103kDa
Observed MW:
103kDa
This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region.
Purification Method:
Affinity purification
Gene ID:
8633
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using UNC5C Rabbit pAb (CAB14809) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
