The UNC5B Polyclonal Antibody (CAB14978) is a valuable tool for research involving UNC5B, a receptor involved in regulating cell survival, migration, and apoptosis. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. It specifically binds to the UNC5B protein, allowing for detection and analysis in various cell types.UNC5B is a member of the UNC5 family of netrin receptors, which play important roles in neuronal development, angiogenesis, and cancer progression. UNC5B in particular has been implicated in cell migration and survival in various contexts, making it a promising target for studies in neurobiology, cardiovascular research, and oncology.
Understanding the molecular mechanisms underlying UNC5B function is crucial for unraveling its role in disease pathogenesis and for developing novel therapeutic approaches. The UNC5B Polyclonal Antibody is an essential tool for researchers looking to explore the functions of UNC5B and its potential implications in various physiological and pathological processes.
Product Name:
UNC5B Rabbit Polyclonal Antibody
SKU:
CAB14978
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 290-377 of human UNC5B (NP_734465.2).
Cell membrane, Membrane raft, Single-pass type I membrane protein.
Calculated MW:
104kDa
Observed MW:
104kDa
This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called dependence receptors (DpRs) which are involved in pro- and anti-apoptotic processes. Many DpRs are involved in embryogenesis and in cancer progression. Two alternatively spliced transcript variants have been described for this gene.
Purification Method:
Affinity purification
Gene ID:
219699
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using UNC5B Rabbit pAb (CAB14978) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
