The UNC13D Polyclonal Antibody (CAB13141) is a valuable tool for researchers studying the UNC13D protein, which plays a crucial role in the exocytosis of cytotoxic granules in natural killer cells and cytotoxic T cells. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.The UNC13D protein, also known as MUNC13-4, is essential for the function of cytolytic cells in the immune system, allowing for the release of cytotoxic granules that target infected or malignant cells.
By targeting UNC13D with this antibody, researchers can investigate the mechanisms underlying cytotoxic cell function, providing insights into immune responses against infections and cancer.The UNC13D Polyclonal Antibody is a valuable tool for studies in immunology and cancer research, enabling the detection and analysis of UNC13D in various cell types. Understanding the role of UNC13D in cytotoxic cell function is essential for developing therapeutic strategies that enhance immune responses against pathogens and tumors.
Product Name:
UNC13D Rabbit Polyclonal Antibody
SKU:
CAB13141
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 891-1090 of human UNC13D (NP_954712.1).
Cytoplasm, Late endosome, Lysosome, Membrane, Peripheral membrane protein, Recycling endosome.
Calculated MW:
123kDa
Observed MW:
123kDa
This gene encodes a protein that is a member of the UNC13 family, containing similar domain structure as other family members but lacking an N-terminal phorbol ester-binding C1 domain present in other Munc13 proteins. The protein appears to play a role in vesicle maturation during exocytosis and is involved in regulation of cytolytic granules secretion. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 3, a genetically heterogeneous, rare autosomal recessive disorder.
Purification Method:
Affinity purification
Gene ID:
201294
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using UNC13D Rabbit pAb (CAB13141) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
