UNC13D Rabbit Polyclonal Antibody (CAB13141)
- SKU:
- CAB13141
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | UNC13D Rabbit Polyclonal Antibody |
SKU: | CAB13141 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 891-1090 of human UNC13D (NP_954712.1). |
Sequence: | LIRK YFCS RIQQ QAET TSEE LGAV TVKA SYRA SEQK LRVE LLSA SSLL PLDS NGSS DPFV QLTL EPRH EFPE LAAR ETQK HKKD LHPL FDET FEFL VPAE PCRK AGAC LLLT VLDY DTLG ADDL EGEA FLPL REVP GLSG SEEP GEVP QTRL PLTY PAPN GDPI LQLL EGRK GDRE AQVF VRLR RHRA KQAS QHAL RPAP |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:1000 - 1:2000 |
Synonyms: | FHL3; HLH3; HPLH3; Munc13-4; UNC13D |
Positive Sample: | A-549,HeLa,HepG2,Mouse lung |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Late endosome, Lysosome, Membrane, Peripheral membrane protein, Recycling endosome. |
Calculated MW: | 123kDa |
Observed MW: | 123kDa |
This gene encodes a protein that is a member of the UNC13 family, containing similar domain structure as other family members but lacking an N-terminal phorbol ester-binding C1 domain present in other Munc13 proteins. The protein appears to play a role in vesicle maturation during exocytosis and is involved in regulation of cytolytic granules secretion. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 3, a genetically heterogeneous, rare autosomal recessive disorder.
Purification Method: | Affinity purification |
Gene ID: | 201294 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |