The UNC13B Polyclonal Antibody (CAB15780) is a valuable tool for researchers studying UNC13B, a critical protein involved in synaptic vesicle priming and neurotransmitter release. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards UNC13B in human samples, making it ideal for use in Western blot applications. By targeting UNC13B, researchers can investigate its role in neuronal communication and potential implications in neurological disorders such as epilepsy, schizophrenia, and Alzheimer's disease.
UNC13B, also known as Munc13-2, is essential for mediating the precise timing and efficiency of neurotransmitter release at synapses. Dysfunction in UNC13B has been linked to impaired synaptic transmission and neurological conditions, highlighting its importance in maintaining proper brain function. By utilizing the UNC13B Polyclonal Antibody, researchers can gain insights into the mechanisms underlying synaptic dysfunction and potentially identify novel therapeutic targets for neurological diseases.
Product Name:
UNC13B Rabbit Polyclonal Antibody
SKU:
CAB15780
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-350 of human UNC13B (NP_006368.3).
This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis.
Purification Method:
Affinity purification
Gene ID:
10497
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using UNC13B Rabbit pAb (CAB15780) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
