UNC13B Rabbit Polyclonal Antibody (CAB15780)
- SKU:
- CAB15780
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | UNC13B Rabbit Polyclonal Antibody |
SKU: | CAB15780 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-350 of human UNC13B (NP_006368.3). |
Sequence: | MSLL CVRV KRAK FQGS PDKF NTYV TLKV QNVK STTV AVRG DQPS WEQD FMFE ISRL DLGL SVEV WNKG LIWD TMVG TVWI ALKT IRQS DEEG PGEW STLE AETL MKDD EICG TRNP TPHK ILLD TRFE LPFD IPEE EARY WTYK WEQI NALG ADNE YSSQ EESQ RKPL PTAA AQCS FEDP DSAV DDRD SDYR SETS NSFP PPYH TASQ PNAS VHQF PVPV RSPQ QLLL QGSS RDSC NDSM QSYD LDYP ERRA ISPT SSSR YGSS CNVS QGSS QLSE LDQY HEQD DDHR ETDS IHSC HSSH SLSR DGQA GFGE QEKP LEVT GQAE KEAA CEPK EMKE DATT HPPP DLVL QK |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | UNC13; MUNC13; Unc13h2; munc13-2; UNC13B |
Positive Sample: | 293T,LO2 |
Conjugate: | Unconjugated |
Cellular Localization: | Cell junction, Cell membrane, Cytoplasm, Membrane, Peripheral membrane protein, synapse. |
Calculated MW: | 181kDa |
Observed MW: | 210kDa |
This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis.
Purification Method: | Affinity purification |
Gene ID: | 10497 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |