UMPS Rabbit Polyclonal Antibody (CAB5492)
- SKU:
- CAB5492
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
Product Name: | UMPS Rabbit Polyclonal Antibody |
SKU: | CAB5492 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 181-480 of human UMPS (NP_000364.1). |
Sequence: | EILE QQKK VDAE TVGR VKRF IQEN VFVA ANHN GSPL SIKE APKE LSFG ARAE LPRI HPVA SKLL RLMQ KKET NLCL SADV SLAR ELLQ LADA LGPS ICML KTHV DILN DFTL DVMK ELIT LAKC HEFL IFED RKFA DIGN TVKK QYEG GIFK IASW ADLV NAHV VPGS GVVK GLQE VGLP LHRG CLLI AEMS STGS LATG DYTR AAVR MAEE HSEF VVGF ISGS RVSM KPEF LHLT PGVQ LEAG GDNL GQQY NSPQ EVIG KRGS DIII VGRG IISA ADRL EAAE MYRK AAWE AYLS RLGV |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | OPRT; UMPS |
Positive Sample: | Jurkat |
Conjugate: | Unconjugated |
Cellular Localization: | cytoplasm, cytosol, nucleus |
Calculated MW: | 52kDa |
Observed MW: | 56kDa |
This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5'-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 7372 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |