The ULK4 Polyclonal Antibody (CAB7471) is a vital tool for researchers studying the ULK4 protein, a key player in the autophagy pathway. This antibody, generated in rabbits, is highly specific to human ULK4 and has been validated for use in Western blot applications. By binding to the ULK4 protein, this antibody allows for accurate detection and analysis in various cell types, making it ideal for investigations in cell biology and disease research.ULK4, a member of the Unc-51-like kinase (ULK) family, is essential for the initiation of autophagy, a cellular process crucial for maintaining homeostasis and responding to stress conditions.
Dysregulation of autophagy has been linked to various diseases including neurodegenerative disorders, cancer, and metabolic disorders. Therefore, understanding the role of ULK4 in autophagy regulation is crucial for developing targeted therapies for these conditions.By utilizing the ULK4 Polyclonal Antibody (CAB7471), researchers can gain valuable insights into the mechanisms underlying autophagy and its implications in disease pathogenesis. This antibody is a valuable tool for advancing scientific understanding and potentially identifying novel therapeutic targets in the field of autophagy research.
Product Name:
ULK4 Rabbit Polyclonal Antibody
SKU:
CAB7471
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human ULK4 (NP_060356.2).
This gene encodes a member of the unc-51-like serine/threonine kinase (STK) family. Members of this protein family play a role in neuronal growth and endocytosis. The encoded protein is likely involved in neurite branching, neurite elongation and neuronal migration. Genome-wide association studies (GWAS) indicate an association of variations in this gene with blood pressure and hypertension. Sequence variations in this gene may also be be associated with psychiatric disorders, including schizophrenia and bipolar disorder. Pseudogenes associated with this gene have been identified and are located on chromosome 15.
Purification Method:
Affinity purification
Gene ID:
54986
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of Rat brain, using ULK4 Rabbit pAb (CAB7471) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
