The ULK1 Polyclonal Antibody (CAB8529) is a valuable tool for researchers studying ULK1, a key regulator of autophagy and cell survival processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and is suitable for use in Western blot applications. By binding specifically to the ULK1 protein, this antibody enables precise detection and analysis in various cell types, making it an essential component of studies in cell biology and disease research.ULK1, a serine/threonine kinase, plays a crucial role in autophagy initiation and maintenance by initiating the formation of autophagosomes.
Dysregulation of ULK1 has been linked to various diseases, including cancer, neurodegenerative disorders, and metabolic conditions. Understanding the function of ULK1 is essential for developing targeted therapies that manipulate autophagy for therapeutic benefit in these pathological contexts. Overall, the ULK1 Polyclonal Antibody provides researchers with a reliable tool to investigate the complex role of ULK1 in cellular processes and disease mechanisms, ultimately contributing to advancements in biomedical research and potential therapeutic interventions.
Product Name:
ULK1 Rabbit Polyclonal Antibody
SKU:
CAB8529
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 350-450 of human ULK1 (NP_003556.1).
Enables identical protein binding activity; protein serine/threonine kinase activity; and small GTPase binding activity. Involved in several processes, including autophagosome assembly; positive regulation by symbiont of host autophagy; and protein phosphorylation. Located in autophagosome; cytosol; and phagophore assembly site membrane. Is extrinsic component of autophagosome membrane; extrinsic component of omegasome membrane; and extrinsic component of phagophore assembly site membrane. Part of Atg1/ULK1 kinase complex.
Purification Method:
Affinity purification
Gene ID:
8408
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from Rat brain, using ULK1 Rabbit pAb (CAB8529) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
