The ULBP1 Monoclonal Antibody is a key tool for researchers studying UL16-binding protein 1 (ULBP1), a cell surface protein involved in immune regulation and the activation of natural killer (NK) cells. This antibody, produced using hybridoma technology, specifically targets ULBP1 in human samples and is optimized for use in various applications, including flow cytometry and immunofluorescence.ULBP1 is a stress-induced ligand that binds to the NKG2D receptor on NK cells, leading to their activation and subsequent killing of target cells. This interaction is crucial for immune surveillance and the elimination of infected or transformed cells.
The ULBP1 Monoclonal Antibody allows for precise detection and quantification of ULBP1 expression, providing insight into its role in immune responses and diseases such as cancer and viral infections.By understanding the function and regulation of ULBP1, researchers can uncover new therapeutic strategies that target the immune system for the treatment of various conditions. The ULBP1 Monoclonal Antibody is a valuable tool for advancing our knowledge of immune responses and developing innovative therapies in the field of immunology and oncology.
Product Name:
ULBP1 Monoclonal Antibody
SKU:
CAB21161
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human ULBP1 (NP_079494.1).
The protein encoded by this gene is a ligand of natural killer group 2, member D (NKG2D), an immune system-activating receptor on NK cells and T-cells. Binding of the encoded ligand to NKG2D leads to activation of several signal transduction pathways, including those of JAK2, STAT5, ERK and PI3K kinase/Akt. Also, in cytomegalovirus-infected cells, this ligand binds the UL16 glycoprotein and is prevented from activating the immune system. Three transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
80329
Clone Number:
ARC3064
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from K-562 cells, using ULBP1 Rabbit mAb (CAB21161) at1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
