The UHRF2 Polyclonal Antibody (CAB13602) is a valuable tool for researchers studying UHRF2, a protein involved in epigenetic regulation and cellular differentiation. This antibody, raised in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications. By targeting the UHRF2 protein, this antibody enables precise detection and analysis in various cell types, making it an essential component for studies in epigenetics and cancer research.UHRF2, also known as ubiquitin-like PHD and RING finger domain-containing protein 2, is a critical player in maintaining DNA methylation patterns and chromatin structure.
Dysregulation of UHRF2 has been implicated in various diseases, including cancer and developmental disorders. By understanding the role of UHRF2 in epigenetic processes, researchers can uncover new insights into disease mechanisms and potentially identify therapeutic targets for intervention.Overall, the UHRF2 Polyclonal Antibody (CAB13602) is a versatile tool for scientists interested in unraveling the complexity of epigenetic regulation and its impact on cellular function. Its specificity and reliability make it an indispensable resource for advancing research in the fields of genetics, oncology, and developmental biology.
Product Name:
UHRF2 Rabbit Polyclonal Antibody
SKU:
CAB13602
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 441-622 of human UHRF2 (NP_690856.1).
This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding.
Purification Method:
Affinity purification
Gene ID:
115426
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded rat Intestine using UHRF2 Rabbit pAb (CAB13602) at dilution of 1:200 (40x lens).Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
