UHRF1 Rabbit Polyclonal Antibody (CAB12589)
- SKU:
- CAB12589
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Description
Product Name: | UHRF1 Rabbit Polyclonal Antibody |
SKU: | CAB12589 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 139-298 of human UHRF1 (NP_037414.3). |
Sequence: | MWDE TELG LYKV NEYV DARD TNMG AWFE AQVV RVTR KAPS RDEP CSST SRPA LEED VIYH VKYD DYPE NGVV QMNS RDVR ARAR TIIK WQDL EVGQ VVML NYNP DNPK ERGF WYDA EISR KRET RTAR ELYA NVVL GDDS LNDC RIIF VDEV FKIE RPGE |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | Np95; hNP95; ICBP90; RNF106; TDRD22; hUHRF1; huNp95; UHRF1 |
Positive Sample: | Mouse brain |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 90kDa |
Observed MW: | 90kDa |
This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12.
Purification Method: | Affinity purification |
Gene ID: | 29128 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |