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UHMK1 Antibody (PACO19248)

SKU:
PACO19248
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
$407

Description

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UHMK1 Antibody (PACO19248)

The UHMK1 Monoclonal Antibody (PACO19248) is a valuable tool for researchers studying UHMK1, a key protein involved in cell signaling pathways and regulation. This antibody, generated through hybridoma technology, exhibits high specificity and sensitivity towards UHMK1 in human samples, making it an excellent choice for various experimental applications.UHMK1, also known as Upstream of N-Ras, is a crucial player in multiple cellular processes, including cell proliferation, differentiation, and survival. Dysregulation of UHMK1 has been linked to various diseases, such as cancer and neurological disorders, making it a promising target for therapeutic interventions.

This monoclonal antibody is validated for use in Western blotting and immunofluorescence studies, allowing for the detection and visualization of UHMK1 in different cell types and tissues. By understanding the role of UHMK1 in cellular function and disease pathology, researchers can uncover valuable insights that may lead to the development of novel treatments and therapies.

Antibody Name:UHMK1 Antibody (PACO19248)
Antibody SKU:PACO19248
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:ELISA:1:1000-1:2000, WB:1:200-1:1000
Species Reactivity:Human, Mouse, Rat
Immunogen:Synthetic peptide of human UHMK1
Form:Liquid
Storage Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:Antigen affinity purification
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageGel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse heart tissue, Primary antibody: PACO19248(UHMK1 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes.
Background:The gene encodes a serine/threonine protein kinase that promotes cell cycle progression through G1 by phosphorylation of the cyclin-dependent kinase inhibitor 1B (p27Kip1), which causes nuclear export and degradation. The encoded protein is also thought to function in the adult nervous system and the gene has been associated with schizophrenia. Alternative splicing results in multiple transcript variants.
Synonyms:U2AF homology motif (UHM) kinase 1
UniProt Protein Function:KIS: a unique kinase that possesses an RNP type RNA-recognition motif (RRM). A proline-directed kinase with a specificity different from the MAP kinases and CDKs. May be involved in trafficking and/or processing of RNA.Protein type: Kinase, protein; EC 2.7.11.1; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Other group; Other-Unique familyChromosomal Location of Human Ortholog: 1q23.3Cellular Component: axon; dendrite cytoplasm; nucleusMolecular Function: ATP binding; mRNA binding; protein binding; protein serine/threonine kinase activity; ribonucleoprotein binding; transferase activityBiological Process: cell cycle arrest; mRNA catabolic process, nonsense-mediated decay; neurite development; peptidyl-serine phosphorylation; positive regulation of translational initiation; protein amino acid autophosphorylation; regulation of alternative nuclear mRNA splicing, via spliceosome; regulation of protein export from nucleus
UniProt Protein Details:
NCBI Summary:The gene encodes a serine/threonine protein kinase that promotes cell cycle progression through G1 by phosphorylation of the cyclin-dependent kinase inhibitor 1B (p27Kip1), which causes nuclear export and degradation. The encoded protein is also thought to function in the adult nervous system and the gene has been associated with schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
UniProt Code:Q8TAS1
NCBI GenInfo Identifier:24211880
NCBI Gene ID:127933
NCBI Accession:Q8TAS1.2
UniProt Secondary Accession:Q8TAS1,Q96C22, A0A0A6YYC2, A8K8K4, G3V1M1
UniProt Related Accession:Q8TAS1
Molecular Weight:39,044 Da
NCBI Full Name:Serine/threonine-protein kinase Kist
NCBI Synonym Full Names:U2AF homology motif (UHM) kinase 1
NCBI Official Symbol:UHMK1  
NCBI Official Synonym Symbols:KIS; KIST; P-CIP2  
NCBI Protein Information:serine/threonine-protein kinase Kist
UniProt Protein Name:Serine/threonine-protein kinase Kist
UniProt Synonym Protein Names:Kinase interacting with stathmin; PAM COOH-terminal interactor protein 2; P-CIP2; U2AF homology motif kinase 1
Protein Family:Serine/threonine-protein kinase
UniProt Gene Name:UHMK1  
UniProt Entry Name:UHMK1_HUMAN
Antibodies
UHMK1 Antibody (PACO13086)
Secondary Antibody
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)
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