The UHMK1 Polyclonal Antibody (PAC013086) is a valuable tool for researchers investigating UHMK1, a serine/threonine protein kinase involved in various cellular processes. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the UHMK1 protein, this antibody enables researchers to detect and analyze UHMK1 in different cell types, making it an ideal choice for studies in cell biology and cancer research.UHMK1, also known as KIS, regulates cell proliferation, survival, and differentiation by phosphorylating a variety of substrates. Its involvement in key signaling pathways makes it a promising target for understanding the molecular mechanisms underlying various diseases, including cancer and neurological disorders.
By studying UHMK1 activity, researchers can gain insights that may lead to the development of new therapeutic strategies aimed at targeting this protein for disease treatment.Overall, the UHMK1 Polyclonal Antibody (PAC013086) offers researchers a reliable tool for investigating the role of UHMK1 in cellular processes and disease pathogenesis, ultimately advancing our understanding of this important protein and its potential implications in various health conditions.
KIS: a unique kinase that possesses an RNP type RNA-recognition motif (RRM). A proline-directed kinase with a specificity different from the MAP kinases and CDKs. May be involved in trafficking and/or processing of RNA.Protein type: Kinase, protein; EC 2.7.11.1; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Other group; Other-Unique familyChromosomal Location of Human Ortholog: 1q23.3Cellular Component: axon; dendrite cytoplasm; nucleusMolecular Function: ATP binding; mRNA binding; protein binding; protein serine/threonine kinase activity; ribonucleoprotein binding; transferase activityBiological Process: cell cycle arrest; mRNA catabolic process, nonsense-mediated decay; neurite development; peptidyl-serine phosphorylation; positive regulation of translational initiation; protein amino acid autophosphorylation; regulation of alternative nuclear mRNA splicing, via spliceosome; regulation of protein export from nucleus
UniProt Protein Details:
NCBI Summary:
The gene encodes a serine/threonine protein kinase that promotes cell cycle progression through G1 by phosphorylation of the cyclin-dependent kinase inhibitor 1B (p27Kip1), which causes nuclear export and degradation. The encoded protein is also thought to function in the adult nervous system and the gene has been associated with schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
