The UGT8 Polyclonal Antibody (CAB16442) is a powerful tool for research involving UGT8, an enzyme involved in the biosynthesis of sulfatide, a key component of myelin in the nervous system. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been extensively validated for use in Western blot applications. By binding specifically to the UGT8 protein, this antibody allows for accurate detection and analysis in various cell types, making it a valuable resource for studies in neuroscience, neurodegenerative diseases, and lipid metabolism.UGT8 is essential for the maintenance and repair of myelin sheaths, ensuring proper nerve function and signaling in the brain and spinal cord.
Dysregulation of UGT8 has been linked to neurological disorders such as multiple sclerosis and peripheral neuropathies. By investigating the role of UGT8 in these conditions, researchers can gain insights into potential therapeutic targets and strategies for treating demyelinating diseases.Overall, the UGT8 Polyclonal Antibody offers researchers a reliable tool for exploring the intricate processes of myelin synthesis and maintenance, as well as the implications of UGT8 dysfunction in neurological disorders. Its specificity and sensitivity make it an invaluable asset for advancing our understanding of the role of sulfatide metabolism in health and disease.
Product Name:
UGT8 Rabbit Polyclonal Antibody
SKU:
CAB16442
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 380-460 of human UGT8 (NP_003351.2).
The protein encoded by this gene belongs to the UDP-glycosyltransferase family. It catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central and peripheral nervous systems. Alternatively spliced transcript variants have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
7368
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from K-562 cells, using UGT8 Rabbit pAb (CAB16442) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
