The UGT1A9 Polyclonal Antibody (CAB1661) is a valuable tool for researchers studying the UGT1A9 enzyme, which is responsible for the glucuronidation of a wide range of endogenous compounds and xenobiotics. This antibody, raised in rabbits, exhibits high specificity and sensitivity towards human samples and has been validated for use in Western blot applications. By binding to the UGT1A9 enzyme, this antibody enables accurate detection and analysis in various cell types, making it ideal for studies in pharmacology, toxicology, and drug metabolism.
UGT1A9 plays a crucial role in the metabolism and elimination of drugs and toxins from the body, thus influencing their pharmacokinetics and bioavailability. Understanding the function and regulation of UGT1A9 is essential for predicting drug interactions, optimizing therapeutic dosages, and minimizing adverse effects in clinical settings. Research on UGT1A9 can provide valuable insights into personalized medicine approaches and drug development strategies tailored to individual patient profiles.
Product Name:
UGT1A9 Rabbit Polyclonal Antibody
SKU:
CAB1661
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 26-250 of human UGT1A9 (NP_066307.1).
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenols.
Purification Method:
Affinity purification
Gene ID:
54600
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse liver, using UGT1A9 Rabbit pAb (CAB1661) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
