The UGT1A6 Polyclonal Antibody (CAB10033) is a specialized tool for studying UGT1A6, an enzyme involved in detoxifying drugs and xenobiotics in the liver. The antibody, produced in rabbits, exhibits high reactivity towards human samples and has been validated for use in Western blot applications. By targeting the UGT1A6 protein, this antibody enables precise detection and analysis in a variety of cell types, making it a valuable asset for research in drug metabolism and liver function.UGT1A6 plays a crucial role in the metabolism and elimination of a wide range of compounds, including medications and environmental toxins.
Dysfunction of this enzyme has been linked to drug toxicity and impaired detoxification processes, highlighting the importance of studying its activity in various disease states. The UGT1A6 Polyclonal Antibody provides researchers with a powerful tool to explore the role of UGT1A6 in drug metabolism, drug interactions, and liver diseases, paving the way for potential therapeutic interventions.
Product Name:
UGT1A6 Rabbit Polyclonal Antibody
SKU:
CAB10033
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 65-270 of human UGT1A6 (NP_001063.2).
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenolic and planar compounds. Alternative splicing in the unique 5' end of this gene results in two transcript variants.
Purification Method:
Affinity purification
Gene ID:
54578
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using UGT1A6 antibody (CAB10033) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
