The UGT1A10 Polyclonal Antibody (CAB16537) is a valuable tool for researchers studying the UGT1A10 enzyme, involved in drug metabolism and detoxification processes in the liver and other tissues. This antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting UGT1A10 in human samples, making it suitable for Western blot analysis.UGT1A10 is a member of the UDP-glucuronosyltransferase (UGT) enzyme family, responsible for conjugating glucuronic acid to various substances for elimination from the body. Its role in drug metabolism makes it a crucial target in pharmaceutical research, as variations in UGT1A10 activity can influence drug efficacy and toxicity.
By using the UGT1A10 Polyclonal Antibody, researchers can analyze UGT1A10 expression levels in different tissues and cell types, aiding in the understanding of drug metabolism pathways and potential drug interactions.Overall, the UGT1A10 Polyclonal Antibody is a reliable tool for investigating the function and regulation of UGT1A10 in drug metabolism processes, offering valuable insights for drug development and personalized medicine approaches.
Product Name:
UGT1A10 Rabbit Polyclonal Antibody
SKU:
CAB16537
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human UGT1A10 (NP_061948.1).
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity on mycophenolic acid, coumarins, and quinolines.
Purification Method:
Affinity purification
Gene ID:
54575
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using UGT1A10 Rabbit pAb (CAB16537) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.