The UGT1A1 Monoclonal Antibody (CAB22995) is specifically designed for research involving the UGT1A1 enzyme, a key player in the metabolism and detoxification of various endogenous and exogenous compounds in the liver. The antibody, derived from mouse hybridoma cells, is highly specific and sensitive for detecting UGT1A1 expression in human samples, making it a valuable tool for researchers studying drug metabolism, liver diseases, and personalized medicine.UGT1A1 is a crucial enzyme involved in the glucuronidation pathway, which facilitates the elimination of drugs, toxins, and bilirubin from the body.
Mutations or variations in the UGT1A1 gene have been linked to conditions such as Gilbert syndrome and increased susceptibility to drug-induced toxicity. By using the UGT1A1 Monoclonal Antibody, researchers can investigate the expression levels and activity of UGT1A1 in different tissues and diseases, shedding light on its role in drug metabolism and liver function.
Product Name:
UGT1A1 Monoclonal Antibody
SKU:
CAB22995
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100-200 of humanUGT1A1 (NP_000454.1).
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome.
Purification Method:
Affinity purification
Gene ID:
54658
Clone Number:
ARC57750
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Confocal imaging of NIH/3T3 cells using UGT1A1 Rabbit mAb (A22995, dilution 1:200) (Red). The cells were counterstained with α-Tubulin Mouse mAb (AC012, dilution 1:400) (Green). DAPI was used for nuclear staining (Blue). Objective: 60x.
