UGT1A1 Monoclonal Antibody (CAB22609)
- SKU:
- CAB22609
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
Product Name: | UGT1A1 Monoclonal Antibody |
SKU: | CAB22609 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 101-200 of human UGT1A1 (NP_000454.1). |
Sequence: | ENDS FLQR VIKT YKKI KKDS AMLL SGCS HLLH NKEL MASL AESS FDVM LTDP FLPC SPIV AQYL SLPT VFFL HALP CSLE FEAT QCPN PFSY VPRP LSSH |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:2000 - 1:4000 |
Synonyms: | GNT1; UGT1; UDPGT; UGT1A; HUG-BR1; BILIQTL1; UDPGT 1-1; UGT1A1 |
Positive Sample: | Hep G2,Mouse liver,Rat liver, |
Conjugate: | Unconjugated |
Cellular Localization: | Endoplasmic reticulum, Endoplasmic reticulum membrane, Microsome, Single-pass membrane protein. |
Calculated MW: | 60kDa |
Observed MW: | 50-60kDa |
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome.
Purification Method: | Affinity purification |
Gene ID: | 54658 |
Clone Number: | ARC57754 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3. |