The UGgt2 Polyclonal Antibody (PAC017363) is a valuable tool for researchers studying UGgt2, a protein involved in protein folding and quality control in the endoplasmic reticulum. This antibody, developed in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to UGgt2, this antibody enables precise detection and analysis of the protein in various cell types, making it an essential component for studies in cell biology and protein quality control mechanisms.UGgt2 is a key player in the process of glycoprotein quality control in the cell, ensuring proper folding and function of glycoproteins.
Dysregulation of UGgt2 activity has been implicated in various diseases, such as neurodegenerative disorders and cancer. Investigating the role of UGgt2 is crucial for understanding the mechanisms of these diseases and developing targeted therapies for them. The UGgt2 Polyclonal Antibody provides researchers with a reliable tool for exploring the function and regulation of UGgt2 in cellular processes, paving the way for new insights and potential therapeutic strategies.
Antibody Name:
UGGT2 Antibody (PACO17363)
Antibody SKU:
PACO17363
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Full length fusion protein
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO17363(UGGT2 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200).
Background:
UDP-glucose:glycoprotein glucosyltransferase (UGT) is a soluble protein of the endoplasmic reticulum (ER) that selectively reglucosylates unfolded glycoproteins, thus providing quality control for protein transport out of the ER.
Synonyms:
UDP-glucose glycoprotein glucosyltransferase 2
UniProt Protein Function:
Function: Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation By similarity.Cofactor: Calcium or manganese.Pathway: Protein modification; protein glycosylation.Subunit structure: Interacts with METTL23. Ref.8Subcellular location: Endoplasmic reticulum lumen. Endoplasmic reticulum-Golgi intermediate compartment Ref.5. Tissue specificity: Higher levels in kidney, pancreas, heart, and skeletal muscle. Ref.1Sequence similarities: Belongs to the glycosyltransferase 8 family.Caution: Has no enzymatic activity towards unfolded RNase B or thyroglobulin (Ref.1).
UniProt Protein Details:
NCBI Summary:
UDP-glucose:glycoprotein glucosyltransferase (UGT) is a soluble protein of the endoplasmic reticulum (ER) that selectively reglucosylates unfolded glycoproteins, thus providing quality control for protein transport out of the ER.[supplied by OMIM, Oct 2009]
