UGGT2 Antibody (PACO17362)
- SKU:
- PACO17362
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
UGGT2 Antibody (PACO17362)
The UGGT2 Polyclonal Antibody (PAC017362) is a valuable tool for researchers studying UGGT2, an enzyme involved in protein quality control in the endoplasmic reticulum. This antibody, produced in rabbits, exhibits strong reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the UGGT2 protein, this antibody enables the detection and analysis of UGGT2 expression in various cell types, making it ideal for investigations in molecular biology and protein quality control research.
UGGT2 plays a crucial role in the proper folding and quality control of glycoproteins, ensuring their correct assembly and function. Dysregulation of UGGT2 has been implicated in various diseases, including neurodegenerative disorders and cancer, highlighting its importance in cellular homeostasis. Studying the function of UGGT2 is essential for unraveling the mechanisms underlying these diseases and developing potential therapeutic interventions targeting protein quality control pathways.
| Antibody Name: | UGGT2 Antibody (PACO17362) |
| Antibody SKU: | PACO17362 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
| Species Reactivity: | Human |
| Immunogen: | Full length fusion protein |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using PACO17362(UGGT2 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO17362(UGGT2 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | UDP-glucose:glycoprotein glucosyltransferase (UGT) is a soluble protein of the endoplasmic reticulum (ER) that selectively reglucosylates unfolded glycoproteins, thus providing quality control for protein transport out of the ER. |
| Synonyms: | UDP-glucose glycoprotein glucosyltransferase 2 |
| UniProt Protein Function: | Function: Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation By similarity.Cofactor: Calcium or manganese.Pathway: Protein modification; protein glycosylation.Subunit structure: Interacts with METTL23. Ref.8Subcellular location: Endoplasmic reticulum lumen. Endoplasmic reticulum-Golgi intermediate compartment Ref.5. Tissue specificity: Higher levels in kidney, pancreas, heart, and skeletal muscle. Ref.1Sequence similarities: Belongs to the glycosyltransferase 8 family.Caution: Has no enzymatic activity towards unfolded RNase B or thyroglobulin (Ref.1). |
| UniProt Protein Details: | |
| NCBI Summary: | UDP-glucose:glycoprotein glucosyltransferase (UGT) is a soluble protein of the endoplasmic reticulum (ER) that selectively reglucosylates unfolded glycoproteins, thus providing quality control for protein transport out of the ER.[supplied by OMIM, Oct 2009] |
| UniProt Code: | Q9NYU1 |
| NCBI GenInfo Identifier: | 311033544 |
| NCBI Gene ID: | 55757 |
| NCBI Accession: | Q9NYU1.4 |
| UniProt Secondary Accession: | Q9NYU1,Q08AD0, Q5JQR8, Q9UFC4 |
| UniProt Related Accession: | Q9NYU1 |
| Molecular Weight: | 174,735 Da |
| NCBI Full Name: | UDP-glucose:glycoprotein glucosyltransferase 2 |
| NCBI Synonym Full Names: | UDP-glucose glycoprotein glucosyltransferase 2 |
| NCBI Official Symbol: | UGGT2Â Â |
| NCBI Official Synonym Symbols: | UGT2; HUGT2; UGCGL2Â Â |
| NCBI Protein Information: | UDP-glucose:glycoprotein glucosyltransferase 2; UDP-Glc:glycoprotein glucosyltransferase 2; UDP--Glc:glycoprotein glucosyltransferase 2; UDP-glucose ceramide glucosyltransferase-like 1; UDP-glucose ceramide glucosyltransferase-like 2 |
| UniProt Protein Name: | UDP-glucose:glycoprotein glucosyltransferase 2 |
| UniProt Synonym Protein Names: | UDP--Glc:glycoprotein glucosyltransferase 2; UDP-glucose ceramide glucosyltransferase-like 1 |
| Protein Family: | UDP-glucose:glycoprotein glucosyltransferase |
| UniProt Gene Name: | UGGT2Â Â |
| UniProt Entry Name: | UGGG2_HUMAN |
| Antibodies |
| UGGT2 Antibody (PACO13077) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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