The UGGT2 Monoclonal Antibody (PAC013077) is a valuable tool for researchers studying UGGT2, an enzyme involved in protein quality control within the endoplasmic reticulum. This antibody, produced using hybridoma technology, exhibits high specificity for human UGGT2 and is optimized for use in immunoprecipitation and immunofluorescence assays.UGGT2, also known as UDP-glucose:glycoprotein glucosyltransferase 2, plays a crucial role in protein folding and quality control by recognizing and reglucosylating misfolded proteins. Dysregulation of UGGT2 activity has been implicated in various diseases, including neurodegenerative disorders and cancer.
By targeting UGGT2 with this antibody, researchers can gain insights into its function and potential therapeutic implications in these disease contexts.This UGGT2 Monoclonal Antibody offers researchers a reliable tool for investigating the role of UGGT2 in protein quality control mechanisms and its impact on disease pathology. Its high specificity and sensitivity make it a valuable asset for studies in molecular biology, biochemistry, and cell biology. Unlock the potential of UGGT2 research with this high-quality antibody.
Function: Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation By similarity.Cofactor: Calcium or manganese.Pathway: Protein modification; protein glycosylation.Subunit structure: Interacts with METTL23. Ref.8Subcellular location: Endoplasmic reticulum lumen. Endoplasmic reticulum-Golgi intermediate compartment Ref.5. Tissue specificity: Higher levels in kidney, pancreas, heart, and skeletal muscle. Ref.1Sequence similarities: Belongs to the glycosyltransferase 8 family.Caution: Has no enzymatic activity towards unfolded RNase B or thyroglobulin (Ref.1).
UniProt Protein Details:
NCBI Summary:
UDP-glucose:glycoprotein glucosyltransferase (UGT) is a soluble protein of the endoplasmic reticulum (ER) that selectively reglucosylates unfolded glycoproteins, thus providing quality control for protein transport out of the ER.[supplied by OMIM, Oct 2009]
