The UGDH Polyclonal Antibody (CAB1210) is a valuable tool for researchers studying UGDH, an essential enzyme involved in the synthesis of hyaluronic acid, a key component of the extracellular matrix. This antibody, produced in rabbits, shows high reactivity with human samples and has been validated for use in Western blot applications. By binding to the UGDH protein, this antibody enables the detection and analysis of UGDH expression in a variety of cell types.UGDH plays a crucial role in the biosynthesis of hyaluronic acid, a major component of the extracellular matrix involved in cell proliferation, migration, and inflammation.
Dysregulation of UGDH expression has been implicated in various diseases, including cancer and inflammatory disorders. Therefore, studying the expression and activity of UGDH using this polyclonal antibody is essential for gaining insights into the role of hyaluronic acid metabolism in these pathological conditions.Researchers in the fields of biochemistry, cell biology, and cancer research will find the UGDH Polyclonal Antibody (CAB1210) to be a valuable tool for investigating the function of UGDH and its potential implications in disease development and progression.
Product Name:
UGDH Rabbit Polyclonal Antibody
SKU:
CAB1210
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 165-494 of human UGDH (NP_003350.1).
The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
7358
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using UGDH Antibody (CAB1210) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
