The UFD1L Polyclonal Antibody (CAB3255) is a research tool designed for studying UFD1L, a protein involved in protein degradation pathways and cellular homeostasis. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. It specifically binds to the UFD1L protein, allowing for accurate detection and analysis in a variety of cell types.UFD1L is a crucial component of the ubiquitin-proteasome system, which plays a pivotal role in the degradation of misfolded or damaged proteins. Dysregulation of this system has been implicated in various diseases, including neurodegenerative disorders and cancer.
Studying UFD1L can provide insights into the mechanisms underlying these conditions and may lead to the development of targeted therapies.With its ability to specifically detect UFD1L protein, the CAB3255 antibody is an invaluable tool for researchers in the fields of molecular biology, cell biology, and cancer research. By elucidating the role of UFD1L in protein degradation pathways, this antibody contributes to the understanding of cellular processes and potential therapeutic targets for a range of diseases.
Product Name:
UFD1L Rabbit Polyclonal Antibody
SKU:
CAB3255
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-307 of human UFD1L (NP_005650.2).
The protein encoded by this gene forms a complex with two other proteins, nuclear protein localization-4 and valosin-containing protein, and this complex is necessary for the degradation of ubiquitinated proteins. In addition, this complex controls the disassembly of the mitotic spindle and the formation of a closed nuclear envelope after mitosis. Mutations in this gene have been associated with Catch 22 syndrome as well as cardiac and craniofacial defects. Alternative splicing results in multiple transcript variants encoding different isoforms. A related pseudogene has been identified on chromosome 18.
Purification Method:
Affinity purification
Gene ID:
7353
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using UFD1L antibody (CAB3255) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
