UCP2 Rabbit Polyclonal Antibody (CAB4178)
- SKU:
- CAB4178
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Description
Product Name: | UCP2 Rabbit Polyclonal Antibody |
SKU: | CAB4178 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 112-211 of human UCP2 (NP_003346.2). |
Sequence: | EHAS IGSR LLAG STTG ALAV AVAQ PTDV VKVR FQAQ ARAG GGRR YQST VNAY KTIA REEG FRGL WKGT SPNV ARNA IVNC AELV TYDL IKDA LLKA NLMT |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | UCPH; BMIQ4; SLC25A8; UCP2 |
Positive Sample: | Raji,A-549,HT-29,RAW264.7,Mouse heart,Rat heart |
Conjugate: | Unconjugated |
Cellular Localization: | Mitochondrion inner membrane, Multi-pass membrane protein. |
Calculated MW: | 33kDa |
Observed MW: | 32kDa |
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'.
Purification Method: | Affinity purification |
Gene ID: | 7351 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |