The Ucn Antibody (PAC021669) is a highly specific and reliable tool for research on Urocortin 1, a peptide hormone involved in stress response and cardiovascular regulation. This polyclonal antibody, produced in rabbits, has been validated for use in various applications, including immunohistochemistry and ELISA.Urocortin 1 is a member of the corticotropin-releasing factor (CRF) family, known for its role in the hypothalamic-pituitary-adrenal (HPA) axis activation during stress. It is also implicated in cardiovascular functions such as blood pressure regulation and heart function.
The Ucn Antibody enables the detection and analysis of Urocortin 1 in biological samples, making it an essential tool for studying stress-related disorders and cardiovascular diseases.Research on Urocortin 1 and its signaling pathways can provide insights into the mechanisms of stress response and potential therapeutic targets for conditions like anxiety, depression, and heart disease. The Ucn Antibody is a valuable resource for scientists and researchers investigating the physiological and pathological roles of Urocortin 1 in various biological systems.
Antibody Name:
UCN Antibody (PACO21669)
Antibody SKU:
PACO21669
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:50-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Synthesized peptide derived from C-terminal of human urocortin.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using urocortin antibody.
Background:
Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta. Alison C. Holloway, Am J Physiol Endocrinol Metab, Jul 2002; 283: E165 - E171. Stacie C. Weninger, Endocrinolog
Synonyms:
UROTENSIN I; UCN;
UniProt Protein Function:
UCN: Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta. Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
Biological Process: regulation of synaptic transmission, glutamatergic; positive regulation of translation; negative regulation of hormone secretion; drinking behavior; response to glucocorticoid stimulus; positive regulation of collagen biosynthetic process; response to pain; negative regulation of cell size; female pregnancy; pancreatic juice secretion; positive regulation of vasodilation; negative regulation of appetite; response to estradiol stimulus; positive regulation of adrenocorticotropic hormone secretion; sensory perception of sound; neuropeptide signaling pathway; positive regulation of cAMP biosynthetic process; negative regulation of blood pressure; inflammatory response; associative learning; neurite development; negative regulation of histone deacetylation; activation of protein kinase A; positive regulation of interleukin-6 production; social behavior; positive regulation of cell growth; positive regulation of peptidyl-serine phosphorylation; positive regulation of vascular permeability; G-protein coupled receptor protein signaling pathway; aerobic respiration; response to oxidative stress; positive regulation of DNA replication; negative regulation of apoptosis
NCBI Summary:
This gene encodes a member of the sauvagine/corticotropin-releasing factor/urotensin I family. The encoded preproprotein is proteolytically processed to generate the mature peptide, an endogenous ligand for both corticotropin-releasing factor receptor 1 and corticotropin-releasing factor receptor 2. In the brain this peptide may be responsible for the effects of stress on appetite. This peptide may also play a role in mood disorders, neurodegeneration, and skeletal system disorders. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin-2. [provided by RefSeq, Feb 2016]
