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UCN Antibody (PACO13069)

SKU:
PACO13069
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€459

Description

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UCN Antibody (PACO13069)

The UCN Antibody (PAC013069) is a critical tool for researchers studying the Urocortin family of peptides, specifically Urocortin (UCN). This polyclonal antibody, raised in rabbits, demonstrates high specificity and sensitivity for detecting UCN in various biological samples. It is validated for use in various applications, including immunohistochemistry, Western blot, and ELISA.UCN is a neuropeptide that plays a key role in stress response and anxiety regulation.

Dysregulation of UCN signaling has been implicated in various psychiatric disorders, making it a promising target for drug development and therapeutic interventions. The UCN Antibody offers researchers a reliable means to study UCN expression and function in different tissues and cell types, facilitating advances in the fields of neuroscience and mental health research.

Antibody Name:UCN Antibody (PACO13069)
Antibody SKU:PACO13069
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:
Species Reactivity:Human, Mouse, Rat
Immunogen:Human UCN
Form:Liquid
Storage Buffer:PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method:Antigen Affinity purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:urocortin;UCN;MGC129974;MGC129975;UI;UROC ;
UniProt Protein Function:UCN: Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta. Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 2p23.3

Cellular Component: dendrite; extracellular region; perikaryon; nerve terminal

Molecular Function:corticotropin-releasing hormone receptor 1 binding; neuropeptide hormone activity; histone deacetylase inhibitor activity; protein binding; corticotropin-releasing hormone receptor 2 binding

Biological Process: regulation of synaptic transmission, glutamatergic; positive regulation of translation; negative regulation of hormone secretion; drinking behavior; response to glucocorticoid stimulus; positive regulation of collagen biosynthetic process; response to pain; negative regulation of cell size; female pregnancy; pancreatic juice secretion; positive regulation of vasodilation; negative regulation of appetite; response to estradiol stimulus; positive regulation of adrenocorticotropic hormone secretion; sensory perception of sound; neuropeptide signaling pathway; positive regulation of cAMP biosynthetic process; negative regulation of blood pressure; inflammatory response; associative learning; neurite development; negative regulation of histone deacetylation; activation of protein kinase A; positive regulation of interleukin-6 production; social behavior; positive regulation of cell growth; positive regulation of peptidyl-serine phosphorylation; positive regulation of vascular permeability; G-protein coupled receptor protein signaling pathway; aerobic respiration; response to oxidative stress; positive regulation of DNA replication; negative regulation of apoptosis

NCBI Summary:This gene encodes a member of the sauvagine/corticotropin-releasing factor/urotensin I family. The encoded preproprotein is proteolytically processed to generate the mature peptide, an endogenous ligand for both corticotropin-releasing factor receptor 1 and corticotropin-releasing factor receptor 2. In the brain this peptide may be responsible for the effects of stress on appetite. This peptide may also play a role in mood disorders, neurodegeneration, and skeletal system disorders. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin-2. [provided by RefSeq, Feb 2016]
UniProt Code:P55089
NCBI GenInfo Identifier:1718059
NCBI Gene ID:7349
NCBI Accession:P55089.1
UniProt Related Accession:P55089
Molecular Weight:
NCBI Full Name:Urocortin
NCBI Synonym Full Names:urocortin
NCBI Official Symbol:UCN  
NCBI Official Synonym Symbols:UI; UROC  
NCBI Protein Information:urocortin
UniProt Protein Name:Urocortin
Protein Family:Urocortin
UniProt Gene Name:UCN  
UniProt Entry Name:UCN1_HUMAN

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