UCN Antibody (PACO05278)
- SKU:
- PACO05278
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
UCN Antibody (PACO05278)
The UCN Monoclonal Antibody (PACO05278) is a valuable tool for researchers studying Urocanate Hydrolase (UCN), an enzyme involved in the metabolism of histidine and the production of urocanic acid. This antibody, derived from a mouse hybridoma, is highly specific for UCN and is suitable for applications such as immunohistochemistry and ELISA.UCN is a key enzyme in the histidine degradation pathway and plays a role in the skin's response to UV exposure.
Research on UCN is important for understanding its function in skin physiology and diseases related to UV radiation, such as skin cancer and photodermatoses. The UCN Monoclonal Antibody is a reliable tool for investigating the expression and localization of UCN in various tissues and cell types, making it a valuable resource for studies in dermatology and skin biology.
| Antibody Name: | UCN Antibody (PACO05278) |
| Antibody SKU: | PACO05278 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:10000, IHC:1:100-1:300 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from the C-terminal region of human Urocortin. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | UCN; Urocortin |
| UniProt Protein Function: | UCN: Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta. Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 2p23.3 Cellular Component: dendrite; extracellular region; perikaryon; nerve terminal Molecular Function:corticotropin-releasing hormone receptor 1 binding; neuropeptide hormone activity; histone deacetylase inhibitor activity; protein binding; corticotropin-releasing hormone receptor 2 binding Biological Process: regulation of synaptic transmission, glutamatergic; positive regulation of translation; negative regulation of hormone secretion; drinking behavior; response to glucocorticoid stimulus; positive regulation of collagen biosynthetic process; response to pain; negative regulation of cell size; female pregnancy; pancreatic juice secretion; positive regulation of vasodilation; negative regulation of appetite; response to estradiol stimulus; positive regulation of adrenocorticotropic hormone secretion; sensory perception of sound; neuropeptide signaling pathway; positive regulation of cAMP biosynthetic process; negative regulation of blood pressure; inflammatory response; associative learning; neurite development; negative regulation of histone deacetylation; activation of protein kinase A; positive regulation of interleukin-6 production; social behavior; positive regulation of cell growth; positive regulation of peptidyl-serine phosphorylation; positive regulation of vascular permeability; G-protein coupled receptor protein signaling pathway; aerobic respiration; response to oxidative stress; positive regulation of DNA replication; negative regulation of apoptosis |
| NCBI Summary: | This gene encodes a member of the sauvagine/corticotropin-releasing factor/urotensin I family. The encoded preproprotein is proteolytically processed to generate the mature peptide, an endogenous ligand for both corticotropin-releasing factor receptor 1 and corticotropin-releasing factor receptor 2. In the brain this peptide may be responsible for the effects of stress on appetite. This peptide may also play a role in mood disorders, neurodegeneration, and skeletal system disorders. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin-2. [provided by RefSeq, Feb 2016] |
| UniProt Code: | P55089 |
| NCBI GenInfo Identifier: | 1718059 |
| NCBI Gene ID: | 7349 |
| NCBI Accession: | P55089.1 |
| UniProt Related Accession: | P55089 |
| Molecular Weight: | |
| NCBI Full Name: | Urocortin |
| NCBI Synonym Full Names: | urocortin |
| NCBI Official Symbol: | UCNÂ Â |
| NCBI Official Synonym Symbols: | UI; UROCÂ Â |
| NCBI Protein Information: | urocortin |
| UniProt Protein Name: | Urocortin |
| Protein Family: | Urocortin |
| UniProt Gene Name: | UCNÂ Â |
| UniProt Entry Name: | UCN1_HUMAN |
Related Products
UCN Antibody (PACO13069)
UCN Antibody (PACO21669)
UCN Antibody (PACO18476)
Mouse UCN / Urocortin ELISA Kit (MOFI00545)
Human UCN / Urocortin ELISA Kit (HUFI01819)
Human Urocortin (UCN) ELISA Kit (HUEB2252)
Mouse Urocortin (Ucn) ELISA Kit (MOEB2000)
