UCK1 Antibody (PACO15700)
- SKU:
- PACO15700
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
UCK1 Antibody (PACO15700)
The UCK1 Polyclonal Antibody (PAC015700) is a valuable tool for researchers studying UCK1, an enzyme involved in nucleotide metabolism and DNA synthesis. This antibody, produced in rabbits, offers high reactivity with human samples and is validated for use in Western blot applications. By binding to the UCK1 protein, researchers can accurately detect and analyze UCK1 levels in various cell types, making it suitable for studies in molecular biology and cancer research.UCK1, also known as uridine-cytidine kinase 1, plays a crucial role in the synthesis of pyrimidine nucleotides, essential for DNA replication and cell growth.
Dysregulation of UCK1 activity has been implicated in various diseases, including cancer and viral infections, making it a promising target for therapeutic intervention. By studying the function of UCK1, researchers can gain valuable insights into the mechanisms underlying these diseases and potentially identify new treatment strategies.
| Antibody Name: | UCK1 Antibody (PACO15700) |
| Antibody SKU: | PACO15700 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:5000, IHC:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Fusion protein of human UCK1 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15700(UCK1 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO15700(UCK1 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | This gene encodes a uridine-cytidine kinase that catalyzes the phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP) but not the phosphorylation of deoxyribonucleosides or purine ribonucleosides. This enzyme can also phosphorylate uridine and cytidine analogs and uses both ATP and GTP as a phosphate donor. Alternative splicing results in multiple splice variants encoding distinct isoforms. |
| Synonyms: | uridine-cytidine kinase 1 |
| UniProt Protein Function: | UCK1: Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4- thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)- benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5- methylcytidine, and N(4)-anisoylcytidine. Belongs to the uridine kinase family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Kinase, other; Nucleotide Metabolism - pyrimidine; Xenobiotic Metabolism - drug metabolism - other enzymes; EC 2.7.1.48Chromosomal Location of Human Ortholog: 9q34.13Cellular Component: cytosolMolecular Function: nucleoside kinase activity; uridine kinase activityBiological Process: pyrimidine base metabolic process; pyrimidine nucleoside salvage |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a uridine-cytidine kinase that catalyzes the phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP) but not the phosphorylation of deoxyribonucleosides or purine ribonucleosides. This enzyme can also phosphorylate uridine and cytidine analogs and uses both ATP and GTP as a phosphate donor. Alternative splicing results in multiple splice variants encoding distinct isoforms. [provided by RefSeq, May 2012] |
| UniProt Code: | Q9HA47 |
| NCBI GenInfo Identifier: | 20455360 |
| NCBI Gene ID: | 83549 |
| NCBI Accession: | Q9HA47.1 |
| UniProt Secondary Accession: | Q9HA47,Q5JT09, Q5JT10, Q5JT12, Q5JT13, Q6IA74, Q96BJ0 |
| UniProt Related Accession: | Q9HA47 |
| Molecular Weight: | 32,275 Da |
| NCBI Full Name: | Uridine-cytidine kinase 1 |
| NCBI Synonym Full Names: | uridine-cytidine kinase 1 |
| NCBI Official Symbol: | UCK1Â Â |
| NCBI Official Synonym Symbols: | URK1Â Â |
| NCBI Protein Information: | uridine-cytidine kinase 1 |
| UniProt Protein Name: | Uridine-cytidine kinase 1 |
| UniProt Synonym Protein Names: | Cytidine monophosphokinase 1; Uridine monophosphokinase 1 |
| Protein Family: | Uridine-cytidine kinase |
| UniProt Gene Name: | UCK1Â Â |
| UniProt Entry Name: | UCK1_HUMAN |
| Antibodies |
| UCK1 Antibody (PACO13066) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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