The UCK1 Polyclonal Antibody (PAC013066) is a valuable tool for researchers studying UCK1, an enzyme involved in the pyrimidine salvage pathway critical for DNA synthesis and repair. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the UCK1 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential tool for investigations in molecular biology and cancer research.
UCK1 plays a vital role in nucleotide metabolism, making it a key target for studying cellular proliferation and genomic stability. Dysregulation of UCK1 has been implicated in various diseases, including cancer, making it a promising candidate for targeted therapies. Understanding the function and regulation of UCK1 is essential for developing novel treatments that target nucleotide metabolism pathways in disease states.
UCK1: Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4- thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)- benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5- methylcytidine, and N(4)-anisoylcytidine. Belongs to the uridine kinase family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Kinase, other; Nucleotide Metabolism - pyrimidine; Xenobiotic Metabolism - drug metabolism - other enzymes; EC 2.7.1.48Chromosomal Location of Human Ortholog: 9q34.13Cellular Component: cytosolMolecular Function: nucleoside kinase activity; uridine kinase activityBiological Process: pyrimidine base metabolic process; pyrimidine nucleoside salvage
UniProt Protein Details:
NCBI Summary:
This gene encodes a uridine-cytidine kinase that catalyzes the phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP) but not the phosphorylation of deoxyribonucleosides or purine ribonucleosides. This enzyme can also phosphorylate uridine and cytidine analogs and uses both ATP and GTP as a phosphate donor. Alternative splicing results in multiple splice variants encoding distinct isoforms. [provided by RefSeq, May 2012]
