The UCHL5 Polyclonal Antibody (CAB7978) is a vital tool for researchers studying UCHL5, a deubiquitinating enzyme involved in the regulation of protein degradation and cellular processes. This antibody, produced using rabbits as the host, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the UCHL5 protein, this antibody allows for accurate detection and analysis in various cell types, making it an essential asset for investigations in molecular biology and disease research.UCHL5, also known as ubiquitin carboxyl-terminal hydrolase L5, plays a crucial role in maintaining protein homeostasis and cellular function by removing ubiquitin molecules from target proteins.
Its function in protein degradation pathways makes it a promising target for understanding diseases related to protein misfolding and aggregation, such as neurodegenerative disorders and cancer. By uncovering the mechanisms of UCHL5 activity, researchers can develop targeted therapies aimed at restoring protein balance and preventing disease progression.
Product Name:
UCHL5 Rabbit Polyclonal Antibody
SKU:
CAB7978
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-328 of human UCHL5 (NP_001186190.1).
Enables endopeptidase inhibitor activity; proteasome binding activity; and thiol-dependent deubiquitinase. Involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of smoothened signaling pathway; and protein deubiquitination. Located in cytosol; nucleolus; and nucleoplasm. Colocalizes with Ino80 complex.
Purification Method:
Affinity purification
Gene ID:
51377
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates, using UCHL5 Rabbit pAb (CAB7978) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 15s.
