The Anti-Uchl3 Antibody (CAB1372) is a high-quality research tool designed for studying Uchl3, a protein involved in the regulation of cellular processes such as protein degradation and turnover. This polyclonal antibody, generated in rabbits, exhibits strong reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the Uchl3 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it well-suited for investigations in cell biology and neurodegenerative diseases.Uchl3 is a deubiquitinating enzyme that plays a crucial role in maintaining protein homeostasis by deubiquitinating and stabilizing target proteins. Dysregulation of Uchl3 has been implicated in the pathogenesis of neurodegenerative disorders such as Parkinson's disease and Alzheimer's disease, making it a promising therapeutic target for drug development.
By studying the function and activity of Uchl3, researchers can gain valuable insights into the underlying mechanisms of these diseases and potentially identify novel treatment strategies.Overall, the Anti-Uchl3 Antibody (CAB1372) is a valuable tool for researchers interested in investigating the role of Uchl3 in protein degradation pathways and neurodegenerative processes. Its high specificity and sensitivity make it an essential component of studies aiming to elucidate the complex mechanisms of cellular regulation and disease pathogenesis.
Product Name:
UCHL3 Rabbit Monoclonal Antibody
SKU:
CAB1372
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human UCHL3 (NP_005993.1).
The protein encoded by this gene is a member of the deubiquitinating enzyme family. Members of this family are proteases that catalyze the removal of ubiquitin from polypeptides and are divided into five classes, depending on the mechanism of catalysis. This protein may hydrolyze the ubiquitinyl-N-epsilon amide bond of ubiquitinated proteins to regenerate ubiquitin for another catalytic cycle. Alternative splicing results in multiple transcript variants that encode different protein isoforms.
Purification Method:
Affinity purification
Gene ID:
7347
Clone Number:
ARC1874
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using UCHL3 Rabbit mAb (CAB1372) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
