The UCHL1 Polyclonal Antibody (CAB0148) is a vital tool for researchers studying UCHL1, a protein associated with neurodegenerative disorders such as Alzheimer's and Parkinson's disease. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the UCHL1 protein, this antibody enables accurate detection and analysis in various cell types, making it an excellent choice for investigations in neuroscience and neurology research.UCHL1, also known as ubiquitin carboxyl-terminal hydrolase L1, plays a crucial role in the maintenance of neuronal function and survival.
Dysregulation of UCHL1 has been implicated in various neurodegenerative diseases, making it a promising target for therapeutic interventions. Understanding the function and regulation of UCHL1 is essential for developing treatments that target neurodegeneration and promote brain health.Overall, the UCHL1 Polyclonal Antibody (CAB0148) is a valuable tool for researchers seeking to investigate the role of UCHL1 in neurodegenerative disorders and further our understanding of potential therapeutic strategies in this field.
Product Name:
PGP9.5/UCHL1 Rabbit Polyclonal Antibody
SKU:
CAB0148
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 59-223 of human PGP9.5/PGP9.5/UCHL1 (NP_004172.2).
The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.
Purification Method:
Affinity purification
Gene ID:
7345
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PGP9.5/PGP9.5/UCHL1 antibody (CAB0148) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
