The UCH37/UCHL5 Monoclonal Antibody is a cutting-edge tool for researchers studying the proteasome system, specifically the UCH37 and UCHL5 proteins. This monoclonal antibody, developed using advanced techniques, offers high specificity and sensitivity for detecting and analyzing these critical proteasome components in various biological samples.UCH37 and UCHL5 are deubiquitinating enzymes involved in the regulation of protein degradation and turnover. Dysregulation of these proteins has been linked to various diseases, including cancer, neurodegenerative disorders, and inflammatory conditions.
By targeting UCH37 and UCHL5 with this monoclonal antibody, researchers can gain valuable insights into the molecular mechanisms underlying these pathologies.With its unparalleled performance in applications such as Western blotting and immunohistochemistry, the UCH37/UCHL5 Monoclonal Antibody is a valuable asset for investigations in cell biology, biochemistry, and drug discovery. By elucidating the roles of UCH37 and UCHL5 in cellular processes, researchers can pave the way for novel therapeutic strategies targeting the proteasome system.
Enables endopeptidase inhibitor activity; proteasome binding activity; and thiol-dependent deubiquitinase. Involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of smoothened signaling pathway; and protein deubiquitination. Located in cytosol; nucleolus; and nucleoplasm. Colocalizes with Ino80 complex.
Purification Method:
Affinity purification
Gene ID:
51377
Clone Number:
ARC60845
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates, using UCH37/UCHL5 Rabbit mAb (CAB23792) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 20s.
