| UniProt Protein Function: | UBXN8: May play a role in reproduction. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, multi-passChromosomal Location of Human Ortholog: 8p12-p11.2Cellular Component: integral to endoplasmic reticulum membraneMolecular Function: protein bindingBiological Process: ER-associated protein catabolic process; single fertilization |
| UniProt Protein Details: | |
| NCBI Summary: | p97 or VCP (valosin-containing protein) is a versatile ATPase complex, and many cofactors are required for the p97 functional diversity. This gene encodes one of the p97 cofactors. This cofactor is a transmembrane protein and localized in the endoplasmic reticulum (ER) membrane. It tethers p97 to the ER membrane via its UBX domain. The association of this cofactor with p97 facilitates efficient ER-associated degradation of misfolded proteins. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2013] |
| UniProt Code: | O00124 |
| NCBI GenInfo Identifier: | 3915830 |
| NCBI Gene ID: | 7993 |
| NCBI Accession: | O00124.2 |
| UniProt Secondary Accession: | O00124,Q7Z6F2 |
| UniProt Related Accession: | O00124 |
| Molecular Weight: | 26,457 Da |
| NCBI Full Name: | UBX domain-containing protein 8 |
| NCBI Synonym Full Names: | UBX domain protein 8 |
| NCBI Official Symbol: | UBXN8Â Â |
| NCBI Official Synonym Symbols: | REP8; UBXD6; D8S2298EÂ Â |
| NCBI Protein Information: | UBX domain-containing protein 8 |
| UniProt Protein Name: | UBX domain-containing protein 8 |
| UniProt Synonym Protein Names: | Reproduction 8 protein; Rep-8 protein; UBX domain-containing protein 6 |
| Protein Family: | UBX domain-containing protein |
| UniProt Gene Name: | UBXN8Â Â |
| UniProt Entry Name: | UBXN8_HUMAN |
