The UBXN8 Polyclonal Antibody (PAC030968) is a vital tool for researchers studying UBXN8, a protein involved in regulating cellular processes such as protein degradation and DNA repair. This antibody is produced in rabbits and is highly specific for detecting human UBXN8 in Western blot experiments. By targeting the UBXN8 protein, researchers can better understand its role in cellular function and potentially uncover new therapeutic targets for diseases related to protein homeostasis and DNA damage repair.UBXN8 is a key player in the cell's quality control mechanisms, helping to prevent the accumulation of misfolded proteins and maintain genomic stability.
Dysregulation of UBXN8 has been linked to various diseases, including neurodegenerative disorders and certain types of cancer. By investigating the function of UBXN8 using this antibody, researchers can gain insights into disease mechanisms and potentially develop novel treatment strategies.Overall, the UBXN8 Polyclonal Antibody (PAC030968) is a valuable tool for researchers interested in exploring the functions of UBXN8 and its implications for human health. Its high specificity and reliability in Western blot assays make it a trusted reagent for studies in biology, biochemistry, and biomedicine.
Antibody Name:
UBXN8 Antibody (PACO30968)
Antibody SKU:
PACO30968
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human UBX domain-containing protein 8 protein (55-270AA)
Immunohistochemistry of paraffin-embedded human testis tissue using PACO30968 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human ovarian cancer using PACO30968 at dilution of 1:100.
Background:
Involved in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins, possibly by tethering VCP to the endoplasmic reticulum membrane. May play a role in reproduction.
Synonyms:
UBX domain-containing protein 8 (Reproduction 8 protein) (Rep-8 protein) (UBX domain-containing protein 6), UBXN8, D8S2298E REP8 UBXD6
UniProt Protein Function:
UBXN8: May play a role in reproduction. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, multi-passChromosomal Location of Human Ortholog: 8p12-p11.2Cellular Component: integral to endoplasmic reticulum membraneMolecular Function: protein bindingBiological Process: ER-associated protein catabolic process; single fertilization
UniProt Protein Details:
NCBI Summary:
p97 or VCP (valosin-containing protein) is a versatile ATPase complex, and many cofactors are required for the p97 functional diversity. This gene encodes one of the p97 cofactors. This cofactor is a transmembrane protein and localized in the endoplasmic reticulum (ER) membrane. It tethers p97 to the ER membrane via its UBX domain. The association of this cofactor with p97 facilitates efficient ER-associated degradation of misfolded proteins. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2013]
