The UBXN2B Polyclonal Antibody (PAC035402) is a valuable tool for researchers studying UBXN2B, a protein involved in cellular processes such as protein degradation and immune response regulation. This antibody, produced using rabbits as the host species, exhibits high reactivity with human samples and has been validated for use in Western blot applications.UBXN2B is a crucial component in the regulation of immune responses, making it a key target for investigation in studies related to immunology and cancer research. By binding to the UBXN2B protein, this antibody enables researchers to detect and analyze its expression in a variety of cell types, providing valuable insights into its role in immune system modulation.
The significance of UBXN2B in immune regulation highlights its potential as a therapeutic target for conditions such as cancer, autoimmune disorders, and chronic inflammatory diseases. By unraveling the functions of UBXN2B, researchers can pave the way for the development of novel treatments that manipulate immune responses for therapeutic benefit.
Immunohistochemistry of paraffin-embedded human lung tissue using PACO35402 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human melanoma using PACO35402 at dilution of 1:100.
Immunofluorescent analysis of HepG2 cells using PACO35402 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L. VCPIP1 is also required, but not its deubiquitinating activity.
UBXN2B: Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L. VCPIP1 is also required, but not its deubiquitinating activity. Belongs to the NSFL1C family.Protein type: Adaptor/scaffold; Endoplasmic reticulumChromosomal Location of Human Ortholog: 8q12.1Cellular Component: Golgi apparatus; endoplasmic reticulum; cytosol; nucleusMolecular Function: ubiquitin binding; protein phosphatase type 1 regulator activityBiological Process: proteasomal ubiquitin-dependent protein catabolic process; regulation of catalytic activity; nuclear envelope reassembly; Golgi organization and biogenesis; autophagic vacuole formation
