The UBXN11 Antibody (PACO05702) is a polyclonal antibody designed for research involving UBXN11, a protein known to play a role in various cellular processes such as protein degradation and cellular signaling. This antibody is produced in rabbits and is highly reactive with human samples, making it suitable for use in Western blot applications. By specifically binding to UBXN11, this antibody enables the detection and analysis of the protein in different cell types, providing valuable insights for studies in cell biology and cancer research.UBXN11, also known as ubiquitin regulator X, is a key player in the ubiquitin-proteasome system, which is responsible for targeting proteins for degradation in the cell.
Dysregulation of this system has been associated with various diseases, including cancer and neurodegenerative disorders. Research on UBXN11 could lead to a better understanding of these diseases and potentially identify new therapeutic targets for intervention.By utilizing the UBXN11 Antibody in your research, you can uncover important insights into the function and regulation of UBXN11, contributing to the advancement of knowledge in cell biology and potential implications for disease treatment strategies.
Synthesized peptide derived from the Internal region of human Socius.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
UBXN11; SOC; UBXD5; PP2243; UBX domain-containing protein 11; Colorectal tumor-associated antigen COA-1; Socius; UBX domain-containing protein 5
UniProt Protein Function:
UBXN11: May be involved in the reorganization of actin cytoskeleton mediated by RND1, RND2 AND RND3. Promotes RHOA activation mediated by GNA12 and GNA13. 8 isoforms of the human protein are produced by alternative splicing.Protein type: CytoskeletalChromosomal Location of Human Ortholog: 1p36.11Cellular Component: cytoplasm; cytoskeletonMolecular Function: protein binding; ubiquitin bindingBiological Process: proteasomal ubiquitin-dependent protein catabolic process
UniProt Protein Details:
NCBI Summary:
This gene encodes a protein with a divergent C-terminal UBX domain. The homologous protein in the rat interacts with members of the Rnd subfamily of Rho GTPases at the cell periphery through its C-terminal region. It also interacts with several heterotrimeric G proteins through their G-alpha subunits and promotes Rho GTPase activation. It is proposed to serve a bidirectional role in the promotion and inhibition of Rho activity through upstream signaling pathways. The 3' coding sequence of this gene contains a polymoprhic region of 24 nt tandem repeats. Several transcripts containing between 1.5 and five repeat units have been reported. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]