The UBD-T2 Polyclonal Antibody (PAC020811) is a vital tool for researchers studying UBD-T2, a protein involved in the ubiquitination pathway. This antibody, produced in rabbits, exhibits high reactivity towards human samples and is validated for use in Western blot applications. By binding to the UBD-T2 protein, researchers can easily detect and analyze its presence in various cell types, making it an essential tool for studies in cell biology and molecular biology.UBD-T2, also known as ubiquitin D, plays a crucial role in the regulation of protein degradation through the ubiquitin-proteasome system. Research shows that dysregulation of ubiquitination pathways, including UBD-T2, is associated with various diseases, including cancer and neurodegenerative disorders.
Understanding the role of UBD-T2 in these pathways is essential for developing targeted therapies that can potentially treat these conditions. The UBD-T2 Polyclonal Antibody is a valuable tool for researchers seeking to further explore the functions of UBD-T2 and its implications in disease pathogenesis. Its high specificity and sensitivity make it an ideal choice for investigating the intricate mechanisms of protein degradation and potential therapeutic interventions.
Antibody Name:
UBTD2 Antibody (PACO20811)
Antibody SKU:
PACO20811
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:30-1:150
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human UBTD2
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20811(UBTD2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
UBTD2 (ubiquitin domain containing 2), also known as DCUBP (dendritic cell-derived ubiquitin-like protein), DC-UbP or SB72, is a 234 amino acid, cytoplasmic and mitochondrial ubiquitin-like (UbL) protein that contains one C-terminal UbL domain. UbL proteins are involved in a variety of cellular processes, including DNA repair, protein sorting, apoptosis, protein degradation, cell division and autophagy. Predominantly expressed in dendritic cells and detected at high levels in tumor cell lines, UBTD2 has been implicated in apoptosis, cellular differentiation and tumorigenesis. The UbL domain of UBTD2 is 55% similar and 28.6% identical to the amino acid, sequence of ubiquitin, but it lacks the Gly-Gly motif that is essential for ubiquitination. As its UbL domain does not actively ubiquitinate proteins, UBTD2 is believed to function as a shuttle factor involved in the ubiquitin system.
Synonyms:
ubiquitin domain containing 2
UniProt Protein Function:
UBTD2: Chromosomal Location of Human Ortholog: 5q35.1Cellular Component: cytoplasmMolecular Function: ubiquitin binding
