The UBR5 Polyclonal Antibody (CAB13816) is a valuable tool for researchers studying UBR5, a protein involved in the ubiquitin-proteasome system that plays a critical role in regulating protein degradation. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. It binds specifically to the UBR5 protein, allowing for precise detection and analysis in various cell types.UBR5 is known to be a key regulator of cellular processes such as cell cycle progression, DNA repair, and apoptosis. Dysregulation of UBR5 has been implicated in various diseases, including cancer, neurodegenerative disorders, and metabolic syndromes.
Therefore, investigating the function of UBR5 is essential for understanding its role in disease pathogenesis and identifying potential therapeutic targets.With its high reactivity and specificity, the UBR5 Polyclonal Antibody provides researchers with a reliable tool for studying UBR5 protein expression and function in different biological contexts. This antibody is an essential resource for studies aimed at unraveling the molecular mechanisms underlying UBR5-mediated cellular processes and its implications in disease development.
Product Name:
UBR5 Rabbit Polyclonal Antibody
SKU:
CAB13816
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 550-760 of human UBR5 (NP_056986.2).
This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation.
Purification Method:
Affinity purification
Gene ID:
51366
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using UBR5 Rabbit pAb (CAB13816) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 60s.
